Product Information
Registration Status: InactiveSIN08132P
THIS PRODUCT HAS BEEN DEREGISTERED!
ANGSOBIDE TABLET 10mg is approved to be sold in Singapore with effective from 1995-04-17. It is marketed by DUOPHARMA (SINGAPORE) PTE LTD, with the registration number of SIN08132P.
This product contains Isosorbide Dinitrate 10mg in the form of TABLET. It is approved for ORAL use.
This product is manufactured by DUOPHARMA (M) SDN BHD in MALAYSIA.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
A vasodilator used in the treatment of angina pectoris. Its actions are similar to nitroglycerin but with a slower onset of action. [PubChem]
Indication
For the prevention of angina pectoris due to coronary artery disease.
Mechanism of Action
Similar to other nitrites and organic nitrates, isosorbide dinitrate is converted to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase (atrial natriuretic peptide receptor A). This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.
Pharmacokinetics
- Absorption
- Absorption of isosorbide dinitrate after oral dosing is nearly complete, but bioavailability is highly variable (10% to 90%), with extensive first-pass metabolism in the liver. The average bioavailability of isosorbide dinitrate is about 25%.
- Distribution
- * 2 to 4 L/kg
- Metabolism
- Hepatic
- Elimination
Toxicity
Symptoms of overdose include reduced cardiac output and hypotension.
Active Ingredient/Synonyms
1,4:3,6-Dianhydrosorbitol 2,5-dinitrate | Carvasin | D-Isosorbide dinitrate | Dianhydrosorbitol 2,5-dinitrate | Dinitrate d'isosorbide | Dinitrato de isosorbida | Dinitroisosorbide | Dinitrosorbide | Flindix | ISDN | Isorbid | Isosorbide 2,5-dinitrate | Isosorbide dinitrate | Isosorbidi dinitras | Nitrosorbide | Sorbide nitrate | Sorbidilat | Sorbidnitrate | Isosorbide Dinitrate |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.