Product Information
Registration Status: ActiveAPO-ACEBUTOLOL TABLET 400mg is approved to be sold in Singapore with effective from 1996-04-04. It is marketed by PHARMAFORTE SINGAPORE PTE LTD, with the registration number of SIN08636P.
This product contains Acebutolol 400mg in the form of TABLET, FILM-COATED. It is approved for ORAL use.
This product is manufactured by APOTEX INC in CANADA.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Description
A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action.
Indication
For the management of hypertension and ventricular premature beats in adults.
Mechanism of Action
Acebutolol is a selective β1-receptor antagonist. Activation of β1-receptors by epinephrine increases the heart rate and the blood pressure, and the heart consumes more oxygen. Acebutolol blocks these receptors, lowering the heart rate and blood pressure. This drug then has the reverse effect of epinephrine. In addition, beta blockers prevent the release of renin, which is a hormone produced by the kidneys which leads to constriction of blood vessels.
Pharmacokinetics
- Absorption
- Well absorbed from the Gl tract with an absolute bioavailability of approximately 40% for the parent compound. In
- Distribution
- Metabolism
- Subject to extensive first-pass hepatic biotransformation (primarily to diacetolol).
- Elimination
Toxicity
Symptoms of overdose include extreme bradycardia, advanced atrioventricular block, intraventricular conduction defects, hypotension, severe congestive heart failure, seizures, and in susceptible patients, bronchospasm, and hypoglycemia.
Active Ingredient/Synonyms
(±)-acebutolol | 3'-acetyl-4'-(2-hydroxy-3-(isopropylamino)propoxy)butyranilide | 5'-butyramido-2'-(2-hydroxy-3-isopropylaminopropoxy)acetophenone | Acebutololum | Acetobutolol | N-(3-acetyl-4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl)butanamide | N-[3-acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]butanamide | Acebutolol |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.