Product Information
Registration Status: ActiveAPO-ACETAZOLAMIDE TABLET 250mg is approved to be sold in Singapore with effective from 1988-05-13. It is marketed by PHARMAFORTE SINGAPORE PTE LTD, with the registration number of SIN01140P.
This product contains Acetazolamide 250mg in the form of TABLET. It is approved for ORAL use.
This product is manufactured by APOTEX INC in CANADA.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Description
One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
Indication
For adjunctive treatment of: edema due to congestive heart failure; drug-induced edema; centrencephalic epilepsies; chronic simple (open-angle) glaucoma
Mechanism of Action
The anticonvulsant activity of Acetazolamide may depend on a direct inhibition of carbonic anhydrase in the CNS, which decreases carbon dioxide tension in the pulmonary alveoli, thus increasing arterial oxygen tension. The diuretic effect depends on the inhibition of carbonic anhydrase, causing a reduction in the availability of hydrogen ions for active transport in the renal tubule lumen. This leads to alkaline urine and an increase in the excretion of bicarbonate, sodium, potassium, and water.
Active Ingredient/Synonyms
2-acetylamino-1,3,4-thiadiazole-5-sulfonamide | 5-acetamido-1,3,4-thiadiazole-2-sulfonamide | 5-acetylamino-1,3,4-thiadiazole-2-sulfonamide | Acetazolamid | Acetazolamida | Acétazolamide | Acetazolamidum | N-[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]acetamide | N-[5-(aminosulfonyl)-1,3,5-thiadiazol-2-yl]acetamide | Acetazolamide |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.