Product InformationRegistration Status: Active
APO-HYDROXYZINE CAPSULE 25mg is approved to be sold in Singapore with effective from 1990-04-20. It is marketed by PHARMAFORTE SINGAPORE PTE LTD, with the registration number of SIN04142P.
This product contains Hydroxyzine 25mg in the form of CAPSULE, LIQUID FILLED. It is approved for ORAL use.
This product is manufactured by ACCUCAPS INDUSTRIES LTD in CANADA.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite cetirizine, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative. [PubChem]
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Mechanism of Action
Hydroxyzine competes with histamine for binding at H1-receptor sites on the effector cell surface, resulting in suppression of histaminic edema, flare, and pruritus. The sedative properties of hydroxyzine occur at the subcortical level of the CNS. Secondary to its central anticholinergic actions, hydroxyzine may be effective as an antiemetic.
- Rapidly absorbed from the gastrointestinal tract
Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Hidroxizina | Hychotine | Hydroksyzyny | Hydroxine | Hydroxizine | Hydroxizinum | Hydroxycine | Hydroxyzin | Hydroxyzine | Hydroxyzinum | Hydroxyzine |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.