Product Information
Registration Status: ActiveSIN00444P
APO-PERPHENAZINE TABLET 4mg is approved to be sold in Singapore with effective from 1988-04-27. It is marketed by PHARMAFORTE SINGAPORE PTE LTD, with the registration number of SIN00444P.
This product contains Perphenazine 4mg in the form of TABLET, FILM-COATED. It is approved for ORAL use.
This product is manufactured by APOTEX INC in CANADA.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. [PubChem]
Indication
For use in the management of the manifestations of psychotic disorders and for the control of severe nausea and vomiting in adults.
Mechanism of Action
Binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity. The mechanism of the anti-emetic effect is due predominantly to blockage of the dopamine D2 neurotransmitter receptors in the chemoreceptor trigger zone and vomiting centre. Perphenazine also binds the alpha andrenergic receptor. This receptor's action is mediated by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Pharmacokinetics
- Absorption
- Absolute bioavailability is 40% following oral administration.
- Distribution
- Metabolism
- Hepatic.
- Elimination
Toxicity
Symptoms of overdose include stupor or coma, and children may have convulsive seizures. Signs of arousal may not occur for 48 hours. Oral LD50=318 mg/kg (rat); IPR LD50=64 mg/kg (mouse)
Active Ingredient/Synonyms
2-(4-[3-(2-chloro-10H-Phenothiazin-10-yl)propyl]-1-piperazinyl)ethanol | 2-chloro-10-(3-(4-(2-Hydroxyethyl)piperazin-1-yl)propyl)phenothiazine | 4-[3-(2-chloro-10H-Phenothiazin-10-yl)propyl]-1-piperazineethanol | 4-[3-(2-Chlorophenothiazin-10-yl)propyl]-1-piperazineethanol | Chlorpiprazine | Etaperazin | Etaperazine | Ethaperazine | gamma-(4-(beta-Hydroxyethyl)piperazin-1-yl)propyl-2-chlorophenothiazine | Perfenazina | Perfenazine | Perphenazin | Perphénazine | Perphenazinum | Perphenazine |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.