Product Information
Registration Status: ActiveAPO-PIROXICAM CAPSULE 20mg is approved to be sold in Singapore with effective from 1991-05-22. It is marketed by PHARMAFORTE SINGAPORE PTE LTD, with the registration number of SIN05893P.
This product contains Piroxicam 20mg in the form of CAPSULE. It is approved for ORAL use.
This product is manufactured by APOTEX INC in CANADA.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Description
A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily. [PubChem]
Indication
For treatment of osteoarthritis and rheumatoid arthritis.
Mechanism of Action
The antiinflammatory effect of Piroxicam may result from the reversible inhibition of cyclooxygenase, causing the peripheral inhibition of prostaglandin synthesis. The prostaglandins are produced by an enzyme called Cox-1. Piroxicam blocks the Cox-1 enzyme, resulting into the disruption of production of prostaglandins. Piroxicam also inhibits the migration of leukocytes into sites of inflammation and prevents the formation of thromboxane A2, an aggregating agent, by the platelets.
Pharmacokinetics
- Absorption
- Well absorbed following oral administration.
- Distribution
- * 0.14 L/kg
- Metabolism
- Renal
- Elimination
Toxicity
Symptoms of overdose include drowsiness, nausea, stomach pain, and/or vomiting.
Active Ingredient/Synonyms
4-Hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazin-3-caboxyamid-1,1-dioxid | Piroxicam | Piroxicam betadex | Piroxicamum | Pyroxycam | Piroxicam |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.