Product InformationRegistration Status: Active
ATROPINE SULPHATE INJECTION 0.6MG/ML is approved to be sold in Singapore with effective from 1989-06-16. It is marketed by ATLANTIC PHARMACEUTICAL (S) PTE LTD, with the registration number of SIN03441P.
This product contains Atropine 0.6mg/ml in the form of INJECTION. It is approved for INTRAVENOUS, SUBCUTANEOUS, INTRAMUSCULAR use.
This product is manufactured by ATLANTIC LABORATORIES CORPN LTD in THAILAND.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
An alkaloid, originally from Atropa belladonna, but found in other plants, mainly solanaceae. [PubChem]
For the treatment of poisoning by susceptible organophosphorous nerve agents having anti-cholinesterase activity (cholinesterase inhibitors) as well as organophosphorous or carbamate insecticides.
Mechanism of Action
Atropine binds to and inhibit muscarinic acetylcholine receptors, producing a wide range of anticholinergic effects.
- Atropine is rapidly and well absorbed after intramuscular administration. Atropine disappears rapidly from the blood and is distributed throughout the various body tissues and fluids.
- Much of the drug is destroyed by enzymatic hydrolysis, particularly in the liver. From 13 to 50% is excreted unchanged in the urine.
Oral, mouse: LD50 = 75 mg/kg. Symptoms of overdose includes widespread paralysis of parasympathetically innervated organs. Dry mucous membranes, widely dilated and nonresponsive pupils, tachycardia, fever and cutaneous flush are especially prominent, as are mental and neurological symptoms. In instances of severe intoxication, respiratory depression, coma, circulatory collapse and death may occur.
(+-)-Atropine | (+-)-Hyoscyamine | (+,-)-Tropyl tropate | (±)-atropine | (±)-hyoscyamine | (3-Endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl tropate | [(1S,5R)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl] 3-hydroxy-2-phenyl-propanoate | 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate | 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl tropate | Atropin | Atropina | Atropine | Atropinum | dl-Hyoscyamine | dl-tropyltropate | Mydriasine | Tropine tropate | Atropine |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.