Product Information

Registration Status: Active

ATROVENT SOLUTION 0.025% is approved to be sold in Singapore with effective from 1989-05-18. It is marketed by BOEHRINGER INGELHEIM SINGAPORE PTE LTD, with the registration number of SIN02815P.

This product contains Ipratropium 0.25mg/ml in the form of SOLUTION. It is approved for RESPIRATORY (INHALATION) use.

This product is manufactured by ISTITUTO DE ANGELI S.R.L. (IDAPH) in ITALY.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.



A muscarinic antagonist structurally related to atropine but often considered safer and more effective for inhalation use. It is used for various bronchial disorders, in rhinitis, and as an antiarrhythmic.


For maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease, including chronic bronchitis and emphysema.

Mechanism of Action

Ipratropium bromide is an anticholinergic agent. It blocks muscarinic cholinergic receptors, without specificity for subtypes, resulting in a decrease in the formation of cyclic guanosine monophosphate (cGMP). Most likely due to actions of cGMP on intracellular calcium, this results in decreased contractility of smooth muscle.


Inhalation (local)-minimal; Nasal-rapid and minimal
* 4.6 L/kg
Partially metabolized to at least 8 metabolites formed primarily via hydrolysis and conjugation. The main metabolites are N-isopropylnortropium methobromide, which is formed by enzymatic hydrolysis of the ester; α-phenylacrylic acid-N-isopropylnortropine-ester methobromide, which is formed by enzymatic loss of a water; and phenylacetic acid-N-isopropylnortropine-ester methobromide, which is formed by enzymatic loss of a CH3OH-group. These metabolites appear to be inactive.


* 2.3 L/min (total clearance of active ingredient)


LD50=1001mg/kg (orally in mice)

Active Ingredient/Synonyms

Ipratropium cation | Ipratropium ion | Ipratropium |

Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.


  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank