Product InformationRegistration Status: Active
BACTROBAN OINTMENT 2% W/W is approved to be sold in Singapore with effective from 1988-04-29. It is marketed by GLAXOSMITHKLINE PTE LTD, with the registration number of SIN00554P.
This product contains Mupirocin 2% w/w in the form of OINTMENT. It is approved for TOPICAL use.
This product is manufactured by SMITHKLINE BEECHAM in PHILIPPINES,SIGMA PHARMACEUTICALS (PTY) LTD in UNITED KINGDOM, andSMITHKLINE BEECHAM PLC in AUSTRALIA.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Mupirocin (pseudomonic acid A, or Bactroban or Centany) is an antibiotic originally isolated from Pseudomonas fluorescens. It is used topically, and is primarily effective against Gram-positive bacteria. Mupirocin is bacteriostatic at low concentrations and bactericidal at high concentrations. Mupirocin has a unique mechanism of action, which is selective binding to bacterial isoleucyl-tRNA synthetase, which halts the incorporation of isoleucine into bacterial proteins. Because this mechanism of action is not shared with any other antibiotic, mupirocin has few problems of antibiotic cross-resistance.
For the treatment of Staphylococci nasal carriers.
Mechanism of Action
Mupirocin reversibly binds to bacterial isoleucyl-tRNA synthetase, an enzyme which promotes the conversion of isoleucine and tRNA to isoleucyl-tRNA. Prevention of this enzymes from functioning properly results in the inhibition of bacterial protein and RNA synthesis.
- No measurable systemic absorption
- Hepatic. Following intravenous or oral administration, mupirocin is rapidly metabolized. The principal metabolite is monic acid, which has no antibacterial activity.
9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3- [(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl] oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoic acid | Mupirocina | Mupirocine | Mupirocinum | Pseudomonic acid | Pseudomonic acid a | Mupirocin |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.