Product Information
Registration Status: ActiveBETOPTIC S STERILE OPHTHALMIC SUSPENSION 0.25% is approved to be sold in Singapore with effective from 1991-05-18. It is marketed by NOVARTIS (SINGAPORE) PTE LTD, with the registration number of SIN05837P.
This product contains Betaxolol 0.25% w/v in the form of SOLUTION. It is approved for OPHTHALMIC use.
This product is manufactured by ALCON-COUVREUR NV in BELGIUM.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Description
A cardioselective beta-1-adrenergic antagonist with no partial agonist activity.
Indication
For the management of hypertension.
Mechanism of Action
Betaxolol selectively blocks catecholamine stimulation of beta(1)-adrenergic receptors in the heart and vascular smooth muscle. This results in a reduction of heart rate, cardiac output, systolic and diastolic blood pressure, and possibly reflex orthostatic hypotension. Betaxolol can also competitively block beta(2)-adrenergic responses in the bronchial and vascular smooth muscles, causing bronchospasm.
Pharmacokinetics
- Absorption
- Absorption of an oral dose is complete. There is a small and consistent first-pass effect resulting in an absolute bioavailability of 89% ± 5% that is unaffected by the concomitant ingestion of food or alcohol.
- Distribution
- Metabolism
- Primarily hepatic. Approximately 15% of the dose administered is excreted as unchanged drug, the remainder being metabolites whose contribution to the clinical effect is negligible.
- Elimination
Toxicity
Oral LD50s are 350 to 400 mg betaxolol/kg in mice and 860 to 980 mg/kg in rats. Predicted symptoms of overdose include bradycardia, congestive heart failure, hypotension, bronchospasm, and hypoglycemia.
Active Ingredient/Synonyms
1-(4-(2-(Cyclopropylmethoxy)ethyl)phenoxy)-3-((1-methylethyl)amino)-2-propanol | 1-(Isopropylamino)-3-[P-(cyclopropylmethoxyethyl)phenoxy]-2-propanol | Betaxololum | Betaxolol |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.