Product Information
Registration Status: ActiveCARDURA TABLET 2mg is approved to be sold in Singapore with effective from 1990-08-16. It is marketed by PFIZER PTE LTD, with the registration number of SIN05014P.
This product contains Doxazosin 2mg in the form of TABLET. It is approved for ORAL use.
This product is manufactured by Pfizer Manufacturing Deutschland GmbH in GERMANY.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Description
Doxazosin is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors. It may be used to mild to moderate hypertension and in the management of symptomatic benign prostatic hyperplasia (BPH). α1-Receptors mediate contraction and hypertrophic growth of smooth muscle cells. Antagonism of these receptors leads to smooth muscle relaxation in the peripheral vasculature and prostate gland.
Indication
For treatment and management of mild to moderate hypertension and urinary obstruction symptoms caused by BPH.
Mechanism of Action
Doxazosin acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation.
Pharmacokinetics
- Absorption
- 65%
- Distribution
- Metabolism
- Hepatic.
- Elimination
Toxicity
Symptoms of overdose include hypotension. Oral LD50 is greater than 1000 mg/kg in mice and rats.
Active Ingredient/Synonyms
1-(4-Amino-6,7-dimethoxy-2-chinazolinyl)-4-(2,3-dihydro-1,4-benzodioxixin-2-ylcarbonyl)piperazin | 1-(4-Amino-6,7-Dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl)piperazin | Doxazosina | Doxazosine | Doxazosinum | Doxazosin |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.