CEFAZIME FOR INJECTION 1g/VIAL

Product Information

Registration Status: Active

CEFAZIME FOR INJECTION 1g/VIAL is approved to be sold in Singapore with effective from 2001-03-26. It is marketed by ZYFAS MEDICAL CO, with the registration number of SIN11470P.

This product contains Ceftazidime 1g/vial, and Sodium Carbonate 121mg/vial in the form of INJECTION. It is approved for INTRAVENOUS, INTRAMUSCULAR use.

This product is manufactured by CJ CORP in KOREA, and in REPUBLIC OF.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Ceftazidime
Sodium Carbonate

Description

Semisynthetic, broad-spectrum antibacterial derived from cephaloridine and used especially for Pseudomonas and other gram-negative infections in debilitated patients.

Indication

For the treatment of patients with infections caused by susceptible strains of organisms in the following diseases: lower respiratory tract infections,skin and skin structure infections, urinary tract infections, bacterial septicemia, bone and joint infections, gynecologic infections, intra abdominal infections (including peritonitis), and central nervous system infections (including meningitis).

Mechanism of Action

The bactericidal activity of ceftazidime results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs).

Pharmacokinetics

Absorption
The absorption of ceftazidime is directly proportional to the size of the dose.
Distribution
Metabolism
Elimination

Clearance

* 115 mL/min

Toxicity

Ceftazidime overdosage has occurred in patients with renal failure. Reactions have included seizure activity, encephalopathy, asterixis, neuromuscular excitability, and coma.

Active Ingredient/Synonyms

CAZ | Ceftazidim | Ceftazidima | Ceftazidime | Ceftazidime anhydrous | Ceftazidimum | Ceftazidime |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.


Description

Sodium Carbonate is the disodium salt of carbonic acid with alkalinizing property. When dissolved in water, sodium carbonate forms carbonic acid and sodium hydroxide. As a strong base, sodium hydroxide neutralizes gastric acid thereby acting as an antacid.

Indication

Used topically for dermatitides, mouthwash, vaginal douche; veterinary use as emergency emetic.Occasionally, for dermatitides topically as a lotion. Medication (Vet): In solution to cleanse skin, in eczema, to soften scabs of ringworm.

Mechanism of Action

Carbon dioxide from the tissues diffuses rapidly into red blood cells, where it is hydrated with water to form carbonic acid. This reaction is accelerated by carbonic anhydrase, an enzyme present in high concentrations in red blood cells. The carbonic acid formed dissociates into bicarbonate and hydrogen ions. Most of the bicarbonate ions diffuse into the plasma. Since the ratio of H2CO3 to dissolved CO2 is constant at equilibrium, pH may be expressed in terms of bicarbonate ion concentration and partial pressure of CO2 by means of the Henderson-Hasselbach equation: pH = pk + log [HCO3-]/aPCO2

Pharmacokinetics

Absorption
The uptake of sodium, via exposure to sodium carbonate, is much less than the uptake of sodium via food. Therefore, sodium carbonate is not expected to be systemically available in the body. Furthermore, an oral uptake of sodium carbonate will result in a neutralization in the stomach due to the gastric acid.
Distribution
Distribution occurs naturally and is confined to the systemic circulation.
Metabolism
None.
Elimination

Toxicity

Man: LD50 (Oral) - 714 mg/kg, Effect: Behavioural,General Anesthetic : GI Ulceration or Bleeding from small intestine. Mouse : LC50 ( Inhalation ) - 1200mg/m3/2h : GI Other Change Mouse : LC50 ( Intraperitoneal ) - 117mg/kg Mouse : LD50 ( Oral) - 6600mg/kg Mouse : LD50 (Subcutaneous ) - 2210 mg/kg Rat : LC50 ( Inhalation ) 2300mg/m3/2H Rat: LD50 (Oral) - 4090 mg/kg

Active Ingredient/Synonyms

Anhydrous sodium carbonate | Carbonic acid sodium salt (1:2) | Carbonic acid, disodium salt | Disodium carbonate | disodium carbonate | Natriumkarbonat | Natrum carbonicum | Soda ash | Soda-ash | Sodium carbonate (anhydrous) | Sodium carbonate anhydrous | Sodium carbonate, anhydrous | Sodium salt of carbonic acid | Sodium carbonate |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank