Product Information
Registration Status: ActiveCEFAZIME FOR INJECTION 1g/VIAL is approved to be sold in Singapore with effective from 2001-03-26. It is marketed by ZYFAS MEDICAL CO, with the registration number of SIN11470P.
This product contains Ceftazidime 1g/vial, and Sodium Carbonate 121mg/vial in the form of INJECTION. It is approved for INTRAVENOUS, INTRAMUSCULAR use.
This product is manufactured by CJ CORP in KOREA, and in REPUBLIC OF.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Description
Semisynthetic, broad-spectrum antibacterial derived from cephaloridine and used especially for Pseudomonas and other gram-negative infections in debilitated patients.
Indication
For the treatment of patients with infections caused by susceptible strains of organisms in the following diseases: lower respiratory tract infections,skin and skin structure infections, urinary tract infections, bacterial septicemia, bone and joint infections, gynecologic infections, intra abdominal infections (including peritonitis), and central nervous system infections (including meningitis).
Mechanism of Action
The bactericidal activity of ceftazidime results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs).
Pharmacokinetics
- Absorption
- The absorption of ceftazidime is directly proportional to the size of the dose.
- Distribution
- Metabolism
- Elimination
Clearance
* 115 mL/min
Toxicity
Ceftazidime overdosage has occurred in patients with renal failure. Reactions have included seizure activity, encephalopathy, asterixis, neuromuscular excitability, and coma.
Active Ingredient/Synonyms
CAZ | Ceftazidim | Ceftazidima | Ceftazidime | Ceftazidime anhydrous | Ceftazidimum | Ceftazidime |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.
Description
Sodium Carbonate is the disodium salt of carbonic acid with alkalinizing property. When dissolved in water, sodium carbonate forms carbonic acid and sodium hydroxide. As a strong base, sodium hydroxide neutralizes gastric acid thereby acting as an antacid.
Indication
Used topically for dermatitides, mouthwash, vaginal douche; veterinary use as emergency emetic.Occasionally, for dermatitides topically as a lotion. Medication (Vet): In solution to cleanse skin, in eczema, to soften scabs of ringworm.
Mechanism of Action
Carbon dioxide from the tissues diffuses rapidly into red blood cells, where it is hydrated with water to form carbonic acid. This reaction is accelerated by carbonic anhydrase, an enzyme present in high concentrations in red blood cells. The carbonic acid formed dissociates into bicarbonate and hydrogen ions. Most of the bicarbonate ions diffuse into the plasma. Since the ratio of H2CO3 to dissolved CO2 is constant at equilibrium, pH may be expressed in terms of bicarbonate ion concentration and partial pressure of CO2 by means of the Henderson-Hasselbach equation: pH = pk + log [HCO3-]/aPCO2
Pharmacokinetics
- Absorption
- The uptake of sodium, via exposure to sodium carbonate, is much less than the uptake of sodium via food. Therefore, sodium carbonate is not expected to be systemically available in the body. Furthermore, an oral uptake of sodium carbonate will result in a neutralization in the stomach due to the gastric acid.
- Distribution
- Distribution occurs naturally and is confined to the systemic circulation.
- Metabolism
- None.
- Elimination
Toxicity
Man: LD50 (Oral) - 714 mg/kg, Effect: Behavioural,General Anesthetic : GI Ulceration or Bleeding from small intestine. Mouse : LC50 ( Inhalation ) - 1200mg/m3/2h : GI Other Change Mouse : LC50 ( Intraperitoneal ) - 117mg/kg Mouse : LD50 ( Oral) - 6600mg/kg Mouse : LD50 (Subcutaneous ) - 2210 mg/kg Rat : LC50 ( Inhalation ) 2300mg/m3/2H Rat: LD50 (Oral) - 4090 mg/kg
Active Ingredient/Synonyms
Anhydrous sodium carbonate | Carbonic acid sodium salt (1:2) | Carbonic acid, disodium salt | Disodium carbonate | disodium carbonate | Natriumkarbonat | Natrum carbonicum | Soda ash | Soda-ash | Sodium carbonate (anhydrous) | Sodium carbonate anhydrous | Sodium carbonate, anhydrous | Sodium salt of carbonic acid | Sodium carbonate |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.