Product InformationRegistration Status: Active
CHLORTRALIM OPHTHALMIC OINTMENT 1% is approved to be sold in Singapore with effective from 1990-05-21. It is marketed by ATLANTIC PHARMACEUTICAL (S) PTE LTD, with the registration number of SIN04539P.
This product contains Chlortetracycline 10mg/g in the form of OINTMENT. It is approved for OPHTHALMIC use.
This product is manufactured by ATLANTIC LABORATORIES CORPN LTD in THAILAND.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Chlortetracycline is a tetracycline antibiotic, the first tetracycline to be identified. It was discovered in 1945 by Benjamin Minge Duggar working at Lederle Laboratories under the supervision of Yellapragada Subbarow. Duggar identified the antibiotic as the product of an actinomycete he cultured from a soil sample collected from Sanborn Field at the University of Missouri. The organism was named Streptomyces aureofaciens and the isolated drug, Aureomycin, because of their golden color.
Used in the manufacuring of medicated animal feeds [FDA Label].
Mechanism of Action
Chlortetracycline, like other tetracyclines, competes for the A site of the bacterial ribosome [T28]. This binding competes with tRNA carrying amino acids preventing the addition of more amino acids to the peptide chain. This inhibition of protein synthesis ultimately inhibits growth and reproduction of the bacterial cell as necessary proteins cannot be synthesized.
- Chortetracycline reaches peak plasma concentation in about 3 hours [A1424]. Its oral bioavailability is 25-30%.
- Chlortetracycline has a volume of distribution of 100 liters [A1424].
- Chlortetracycline is not known to undergo significant metabolism [A1424].
The acute oral LD50 in mice is 2314mg/kg [MSDS].The most common adverse effects of tertacylines are gastrointestinal disturbances, and staining of teeth and bone. Some occurences of dental hypoplasia and bone deformity have been noted [T28]. In pregnant women tetracyclines may produce hepatotoxicity.
Chlortetracycline | Chlortetracycline |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.