Product Information
Registration Status: ActiveCITANEST OCTAPRESSIN INJECTION is approved to be sold in Singapore with effective from 1991-03-05. It is marketed by DENTSPLY (SINGAPORE) PTE LTD, with the registration number of SIN06175P.
This product contains Felypressin 0.066 iu/2.2ml, and Prilocaine 66mg/2.2ml in the form of INJECTION. It is approved for BUCCAL use.
This product is manufactured by ASTRA PHARMACEUTICALS PTY LTD in AUSTRALIA.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Description
A synthetic nonapeptide comprising cysteinyl, phenylalanyl, phenylalanyl, glutaminyl, asparaginyl, cysteinyl, prolyl, lysyl, and glycinamide residues in sequence, with a disulfide bridge joining the two cysteine residues. Its antidiuretic effects are less than those of vasopressin. It is used as a vasoconstrictor in local anaesthetic injections for dental use, and is an ingredient of preparations that have been used for treatment of pain and inflammation of the mouth.
Indication
For use as an alternative to adrenaline as a localising agent, provided that local ischaemia is not essential.
Mechanism of Action
Felypressin binds to the vasopressin receptor V1a. This causes contraction of the smooth muscle in the vascular bed, especially capillaries, small arterioles and venules.
Active Ingredient/Synonyms
2-(L-phenylalanine)-8-L-lysinevasopressin | Felipresina | Felypressin | Felypressine | Felypressinum | PLV-2 | Felypressin |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.
Description
A local anesthetic that is similar pharmacologically to lidocaine. Currently, it is used most often for infiltration anesthesia in dentistry. (From AMA Drug Evaluations Annual, 1992, p165)
Indication
Used as a local anaesthetic and is often used in dentistry.
Mechanism of Action
Prilocaine acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. The antiarrhythmic actions are mediated through effects on sodium channels in Purkinje fibers.
Active Ingredient/Synonyms
2-(Propylamino)-O-propionotoluidide | 2-Methyl-alpha-propylaminopropionanilide | alpha-N-Propylamino-2-methylpropionanilide | N-(2-Methylphenyl)-2-(propylamino)propanamide | O-Methyl-2-propylaminopropionanilide | O-Methyl-alpha-propylaminopropionanilide | Prilocain | Prilocaina | Prilocaïne | Prilocaine base | Prilocainum | Propitocaine | Prilocaine |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.