CLOXACAP 250 CAPSULE 250mg

Product Information

Registration Status: Active

CLOXACAP 250 CAPSULE 250mg is approved to be sold in Singapore with effective from 1990-08-30. It is marketed by GOLDPLUS UNIVERSAL PTE LTD, with the registration number of SIN05036P.

This product contains Cloxacillin 250mg in the form of CAPSULE. It is approved for ORAL use.

This product is manufactured by HOVID BHD in MALAYSIA.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Cloxacillin

Description

A semi-synthetic antibiotic that is a chlorinated derivative of oxacillin.

Indication

Used to treat infections caused by penicillinase-producing staphylococci, including pneumococci, group A beta-hemolytic streptococci, and penicillin G-sensitive and penicillin G-resistant staphylococci.

Mechanism of Action

By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, cloxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cloxacillin interferes with an autolysin inhibitor.

Pharmacokinetics

Absorption
Well absorbed from the gastrointestinal tract.
Distribution
Metabolism
Elimination

Toxicity

Oral LD50 in rat and mouse is 5000 mg/kg. Intravenous LD50 in rat is 1660 mg/kg. Symptoms of overdose include wheezing, tightness in the chest, fever, itching, bad cough, blue skin color, fits, and swelling of face, lips, tongue, or throat.

Active Ingredient/Synonyms

(2S,5R,6R)-6-({[3-(2-chlorophenyl)-5-methylisoxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid | (3-(O-Chlorophenyl)-5-methyl-4-isoxazolyl)penicillin | 6-(3-(O-Chlorophenyl)-5-methyl-4-isoxazolecarboxamido)penicillanic acid | Cloxacilina | Cloxacilline | Cloxacillinum | Cloxacillin |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank