Product Information
Registration Status: ActiveSIN11497P
CLOZAPINE TABLET 25mg is approved to be sold in Singapore with effective from 2001-04-26. It is marketed by PHARMLINE MARKETING PTE LTD, with the registration number of SIN11497P.
This product contains Clozapine 25mg in the form of TABLET. It is approved for ORAL use.
This product is manufactured by ROTTENDORF PHARMA GMBH in SPAIN, andSynthon Hispania in GERMANY.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
A tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent. [PubChem]
Indication
For use in patients with treatment-resistant schizophrenia.
Mechanism of Action
Clozapine's antipsychotic action is likely mediated through a combination of antogistic effects at D2 receptors in the mesolimbic pathway and 5-HT2A receptors in the frontal cortex. D2 antagonism relieves positive symptoms while 5-HT2A antagonism alleviates negative symptoms.
Pharmacokinetics
- Absorption
- Rapid and almost complete
- Distribution
- Metabolism
- Hepatic
- Elimination
Toxicity
Clozapine carries a black-box warning for agranulocytosis.
Active Ingredient/Synonyms
Clozapin | Clozapina | Clozapine | Clozapinum | Clozapine |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.