Product Information
Registration Status: ActiveCLOZARIL TABLET 25mg is approved to be sold in Singapore with effective from 1992-06-11. It is marketed by MYLAN PHARMACEUTICALS PTE LTD, with the registration number of SIN07234P.
This product contains Clozapine 25mg in the form of TABLET, FILM-COATED. It is approved for ORAL use.
This product is manufactured by Novartis Saglik in TURKEY.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Description
A tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent. [PubChem]
Indication
For use in patients with treatment-resistant schizophrenia.
Mechanism of Action
Clozapine's antipsychotic action is likely mediated through a combination of antogistic effects at D2 receptors in the mesolimbic pathway and 5-HT2A receptors in the frontal cortex. D2 antagonism relieves positive symptoms while 5-HT2A antagonism alleviates negative symptoms.
Pharmacokinetics
- Absorption
- Rapid and almost complete
- Distribution
- Metabolism
- Hepatic
- Elimination
Toxicity
Clozapine carries a black-box warning for agranulocytosis.
Active Ingredient/Synonyms
Clozapin | Clozapina | Clozapine | Clozapinum | Clozapine |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.