Product Information
Registration Status: ActiveCOGENTIN INJECTION 2mg/2ml is approved to be sold in Singapore with effective from 1991-01-29. It is marketed by A. MENARINI SINGAPORE PTE LTD, with the registration number of SIN05387P.
This product contains Benztropine 2mg/2ml in the form of INJECTION. It is approved for INTRAVENOUS, INTRAMUSCULAR use.
This product is manufactured by Hospira Inc. in UNITED STATES.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Description
Benzotropine is a centrally-acting, antimuscarinic agent used as an adjunct in the treatment of Parkinson’s disease. It may also be used to treat extrapyramidal reactions, such as dystonia and Parkinsonism, caused by antipsychotics (e.g. phenothiazines). Symptoms of Parkinson’s disease and extrapyramidal reactions arise from decreases in dopaminergic activity which creates an imbalance between dopaminergic and cholinergic activity. Anticholinergic therapy is thought to aid in restoring this balance leading to relief of symptoms. In addition to its anticholinergic effects, benztropine also inhibits the reuptake of dopamine at nerve terminals via the dopamine transporter. Benzotropine also produces antagonistic effects at the histamine H1 receptor.
Indication
For use as an adjunct in the therapy of all forms of parkinsonism and also for use in the control of extrapyramidal disorders due to neuroleptic drugs.
Mechanism of Action
Benztropine is a selective M1 muscarinic acetylcholine receptor antagonist. It is able to discriminate between the M1 (cortical or neuronal) and the peripheral muscarinic subtypes (cardiac and glandular). Benztropine partially blocks cholinergic activity in the CNS, which is responsible for the symptoms of Parkinson's disease. It is also thought to increase the availability of dopamine, a brain chemical that is critical in the initiation and smooth control of voluntary muscle movement.
Pharmacokinetics
- Absorption
- Onset of action is 1-2 hours following oral administration. The onset of action is within minutes when administered by IM or IV injection.
- Distribution
- Metabolism
- Elimination
Toxicity
Signs of overdose include confusion, nervousness, listlessness, hallucinations, dizziness; muscle weakness, ataxia, dry mouth, mydriasis, blurred vision, palpitations, tachycardia, elevated blood pressure, nausea, vomiting, dysuria, numbness of fingers, headache, delirium, coma, shock, convulsions, respiratory arrest, anhidrosis, hyperthermia, glaucoma, and constipation.
Active Ingredient/Synonyms
3-alpha-(diphenylmethoxy)tropane | 3alpha-(Diphenylmethoxy)-1alphah,5alphah-tropane | 3alpha-(Diphenylmethoxy)tropane | 3alpha-Benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane | 3endo-benzhydryloxytropane | 3α-(diphenylmethoxy)-1αH,5αH-tropane | 3α-(diphenylmethoxy)tropane | 3α-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane | Benzatropina | Benzatropinum | Benzhydryl 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ether | Benztropine | Tropine Benzohydryl Ether | Benzatropine |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.