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CYCLOGYL STERILE OPHTHALMIC SOLUTION 1%

Product Information

Registration Status: Active

SIN04714P

CYCLOGYL STERILE OPHTHALMIC SOLUTION 1% is approved to be sold in Singapore with effective from 1990-06-13. It is marketed by ALCON PTE LTD, with the registration number of SIN04714P.

This product contains Cyclopentolate 1% in the form of SOLUTION. It is approved for OPHTHALMIC use.

This product is manufactured by ALCON-COUVREUR NV in BELGIUM.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Product Reference
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Description

A parasympatholytic anticholinergic used solely to obtain mydriasis or cycloplegia. [PubChem]

Indication

Used mainly to produce mydriasis and cycloplegia for diagnostic purposes.

Mechanism of Action

By blocking muscarinic receptors, cyclopentolate produces dilatation of the pupil (mydriasis) and prevents the eye from accommodating for near vision (cycloplegia).

Pharmacokinetics

Absorption
Absorbed following ophthalmic administration.
Distribution
Metabolism
Elimination

Toxicity

Oral LD50 in the rat is 4000 mg/kg and 960 mg/kg in the mouse. Symptoms of overdose include tachycardia, dizziness, dry mouth, behavioral disturbances, uncoordination and drowsiness.

Active Ingredient/Synonyms

(+-)-Cyclopentolate | (±)-cyclopentolate | 1-Hydroxy-alpha-phenylcyclopentaneacetic acid 2-(dimethylamino)ethyl ester | 2-(dimethylamino)Ethyl 1-hydroxy-alpha-phenylcyclopentaneacetate | 2-(dimethylamino)Ethyl 2-(1-hydroxycyclopentyl)-2-phenylacetate | 2-Phenyl-2-(1-hydroxycyclopentyl)ethanoic acid beta-(dimethylamino)ethyl ester | alpha-(1-Hydroxycyclopentyl)benzeneacetic acid 2-(dimethylamino)ethyl ester | beta-(dimethylamino)Ethyl (1-hydroxycyclopentyl)phenylacetate | beta-Dimethylaminoethyl (1-hydroxycyclopentyl)phenylacetate | Ciclopentolato | Cyclopentolate | Cyclopentolatum | α-(1-hydroxycyclopentyl)benzeneacetic acid 2-(dimethylamino)ethyl ester | β-dimethylaminoethyl (1-hydroxycyclopentyl)phenylacetate | Cyclopentolate |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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