Product Information
Registration Status: ActiveSIN12499P
DAC POWDER FOR INJECTION 200mg/VIAL is approved to be sold in Singapore with effective from 2004-10-01. It is marketed by SHOEI UNIVERSAL CORPORATION PTE LTD, with the registration number of SIN12499P.
This product contains Dacarbazine 200mg/vial in the form of INJECTION, POWDER, FOR SOLUTION. It is approved for INTRAVENOUS use.
This product is manufactured by DAE HAN NEW PHARM. CO. LTD. in KOREA, and in REPUBLIC OF.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma.
Indication
For the treatment of metastatic malignant melanoma. In addition, dacarbazine is also indicated for Hodgkin's disease as a secondary-line therapy when used in combination with other antineoplastic agents.
Mechanism of Action
The mechanism of action is not known, but appears to exert cytotoxic effects via its action as an alkylating agent. Other theories include DNA synthesis inhibition by its action as a purine analog, and interaction with SH groups. Dacarbazine is not cell cycle-phase specific.
Pharmacokinetics
- Absorption
- Erratic, slow and incomplete.
- Distribution
- Metabolism
- Hepatic
- Elimination
Toxicity
LD50=350mg/kg (orally in mice)
Active Ingredient/Synonyms
4-(3,3-dimethyl-1-triazeno)imidazole-5-carboxamide | 4-(5)-(3,3-dimethyl-1-triazeno)imidazole-5(4)-carboxamide | 4-(dimethyltriazeno)imidazole-5-carboxamide | 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide | 5-(3,3-dimethyltriazeno)imidazole-4-carboxamide | 5-(dimethyltriazeno)imidazole-4-carboxamide | Biocarbazine | Dacarbazin | Dacarbazina | Dacarbazine | Dacarbazinum | DIC | DTIC | ICDMT | Dacarbazine |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.