Product Information
Registration Status: ActiveDBL BLEOMYCIN SULFATE FOR INJECTION 15000 IU/VIAL is approved to be sold in Singapore with effective from 1995-10-26. It is marketed by HOSPIRA SINGAPORE PTE LTD, with the registration number of SIN08426P.
This product contains Bleomycin 15000 iu/vial in the form of INJECTION, POWDER, FOR SOLUTION. It is approved for INTRAVENOUS, SUBCUTANEOUS, INTRAMUSCULAR use.
This product is manufactured by Hospira Australia Pty Ltd in AUSTRALIA, andZydus Hospira Oncology Private Limited (ZHOPL) in INDIA.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Description
A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin.
Indication
For palliative treatment in the management malignant neoplasm (trachea, bronchus, lung), squamous cell carcinoma, and lymphomas.
Mechanism of Action
Although the exact mechanism of action of bleomycin is unknown, available evidence would seem to indicate that the main mode of action is the inhibition of DNA synthesis with some evidence of lesser inhibition of RNA and protein synthesis. DNA cleavage by bleomycin depends on oxygen and metal ions, at least in vitro. It is believed that bleomycin chelates metal ions (primarily iron) producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
Pharmacokinetics
- Absorption
- Systemic absorption is approximately 45%.
- Distribution
- Metabolism
- Hepatic
- Elimination
Toxicity
Excessive exposure may cause fever, chills, nausea, vomiting, mental, confusion, and wheezing. Bleomycin may cause irritation to eyes, skin and respiratory tract. It may also cause a darkening or thickening of the skin. It may cause an allergic reaction.
Active Ingredient/Synonyms
Bleocin | Bleomicin | Bleomicina | Bleomycin A2 | Bleomycine | Bleomycinum | BLM | Bleomycin |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.