Product Information
Registration Status: ActiveDBL DACARBAZINE FOR INJECTION 200mg is approved to be sold in Singapore with effective from 1991-08-07. It is marketed by HOSPIRA SINGAPORE PTE LTD, with the registration number of SIN06424P.
This product contains Dacarbazine 200mg/vial in the form of INJECTION, POWDER, FOR SOLUTION. It is approved for INTRAVENOUS use.
This product is manufactured by Zydus Hospira Oncology PTE LTD in INDIA.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Description
An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma.
Indication
For the treatment of metastatic malignant melanoma. In addition, dacarbazine is also indicated for Hodgkin's disease as a secondary-line therapy when used in combination with other antineoplastic agents.
Mechanism of Action
The mechanism of action is not known, but appears to exert cytotoxic effects via its action as an alkylating agent. Other theories include DNA synthesis inhibition by its action as a purine analog, and interaction with SH groups. Dacarbazine is not cell cycle-phase specific.
Pharmacokinetics
- Absorption
- Erratic, slow and incomplete.
- Distribution
- Metabolism
- Hepatic
- Elimination
Toxicity
LD50=350mg/kg (orally in mice)
Active Ingredient/Synonyms
4-(3,3-dimethyl-1-triazeno)imidazole-5-carboxamide | 4-(5)-(3,3-dimethyl-1-triazeno)imidazole-5(4)-carboxamide | 4-(dimethyltriazeno)imidazole-5-carboxamide | 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide | 5-(3,3-dimethyltriazeno)imidazole-4-carboxamide | 5-(dimethyltriazeno)imidazole-4-carboxamide | Biocarbazine | Dacarbazin | Dacarbazina | Dacarbazine | Dacarbazinum | DIC | DTIC | ICDMT | Dacarbazine |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.