Product Information
Registration Status: ActiveSIN06766P
DBL PENTAMIDINE ISETHIONATE FOR INJECTION BP 300mg/VIAL is approved to be sold in Singapore with effective from 1992-01-13. It is marketed by HOSPIRA SINGAPORE PTE LTD, with the registration number of SIN06766P.
This product contains Pentamidine 300mg/vial in the form of INJECTION, POWDER, FOR SOLUTION. It is approved for INTRAVENOUS use.
This product is manufactured by HOSPIRA AUSTRALIA PTY LTD in AUSTRALIA.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. [PubChem]
Indication
For the treatment of pneumonia due to Pneumocystis carinii.
Mechanism of Action
The mode of action of pentamidine is not fully understood. It is thought that the drug interferes with nuclear metabolism producing inhibition of the synthesis of DNA, RNA, phospholipids, and proteins.
Pharmacokinetics
- Absorption
- Absorbed poorly through the gastrointestinal tract and is usually administered parenterally.
- Distribution
- Metabolism
- Hepatic.
- Elimination
Toxicity
Symptoms of overdose include pain, nausea, anorexia, hypotension, fever, rash, bad taste in mouth, confusion/hallucinations, dizziness, and diarrhea.
Active Ingredient/Synonyms
1,5-Bis(4-amidinophenoxy)pentane | 4,4'-(1,5-Pentanediylbis(oxy))bis-benzenecarboximidamide | 4,4'-(Pentamethylenedioxy)dibenzamidine | 4,4'-Diamidinodiphenoxypentane | P,P'-(pentamethylenedioxy)dibenzamidine | Pentamidin | Pentamidina | Pentamidindiisetionat | Pentamidine | Pentamidinum | Pentamidine |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.