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DEANXIT TABLET

Product Information

Registration Status: Active

SIN00913P

DEANXIT TABLET is approved to be sold in Singapore with effective from 1988-09-05. It is marketed by LUNDBECK SINGAPORE PTE LTD, with the registration number of SIN00913P.

This product contains Flupentixol 0.5mg, and Melitracen 10mg in the form of TABLET, SUGAR-COATED. It is approved for ORAL use.

This product is manufactured by H LUNDBECK A/S in DENMARK.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Product Reference
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Description

Flupentixol is an antipsychotic neuroleptic drug. It is a thioxanthene, and therefore closely related to the phenothiazines. Its primary use is as a long acting injection given two or three weekly to people with schizophrenia who have a poor compliance with medication and suffer frequent relapses of illness. It is a D1 and D2 receptor antagonist. It is not approved in the United States.

Indication

For use in the treatment of schizophrenia and depression

Mechanism of Action

Flupenthixol is a thioxanthene antipsychotic. The mechanism of action of Flupenthixol is not completely understood. Flupenthixol is a powerful antagonist of both D1 and D2 dopamine receptors, and an alpha-adrenergic receptor antagonist. It's antipsychotic activity is thought to be related to blocks postsynaptic dopamine receptors in the CNS.

Pharmacokinetics

Absorption
Fairly slow and incomplete after oral administration
Distribution
Metabolism
Mainly hepatic
Elimination

Toxicity

LD50=300 mk/kg (Oral in mice); LD50=791 mg/kg (Oral in rats); LD50=87 mk/kg (IV in mice); LD50=37 mg/kg (IV in rats)

Active Ingredient/Synonyms

Flupenthixol | Flupenthixole | Flupentixol | Flupentixolo | Flupentixolum | Flupentixol |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.


Active Ingredient/Synonyms

Melitracen | Melitracen |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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