Product Information
Registration Status: ActiveSIN00913P
DEANXIT TABLET is approved to be sold in Singapore with effective from 1988-09-05. It is marketed by LUNDBECK SINGAPORE PTE LTD, with the registration number of SIN00913P.
This product contains Flupentixol 0.5mg, and Melitracen 10mg in the form of TABLET, SUGAR-COATED. It is approved for ORAL use.
This product is manufactured by H LUNDBECK A/S in DENMARK.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
Flupentixol is an antipsychotic neuroleptic drug. It is a thioxanthene, and therefore closely related to the phenothiazines. Its primary use is as a long acting injection given two or three weekly to people with schizophrenia who have a poor compliance with medication and suffer frequent relapses of illness. It is a D1 and D2 receptor antagonist. It is not approved in the United States.
Indication
For use in the treatment of schizophrenia and depression
Mechanism of Action
Flupenthixol is a thioxanthene antipsychotic. The mechanism of action of Flupenthixol is not completely understood. Flupenthixol is a powerful antagonist of both D1 and D2 dopamine receptors, and an alpha-adrenergic receptor antagonist. It's antipsychotic activity is thought to be related to blocks postsynaptic dopamine receptors in the CNS.
Pharmacokinetics
- Absorption
- Fairly slow and incomplete after oral administration
- Distribution
- Metabolism
- Mainly hepatic
- Elimination
Toxicity
LD50=300 mk/kg (Oral in mice); LD50=791 mg/kg (Oral in rats); LD50=87 mk/kg (IV in mice); LD50=37 mg/kg (IV in rats)
Active Ingredient/Synonyms
Flupenthixol | Flupenthixole | Flupentixol | Flupentixolo | Flupentixolum | Flupentixol |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.
Active Ingredient/Synonyms
Melitracen | Melitracen |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.