Product InformationRegistration Status: Active
DEVODIL 200 TABLET 200mg is approved to be sold in Singapore with effective from 1998-07-08. It is marketed by GOLDPLUS UNIVERSAL PTE LTD, with the registration number of SIN09937P.
This product contains Sulpiride 200mg in the form of TABLET. It is approved for ORAL use.
This product is manufactured by REMEDICA LTD in CYPRUS.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. (From Merck Index, 11th ed)
Sulpiride is indicated for the treatment of schizophrenia.
Mechanism of Action
In contrast to most other neuroleptics which block both dopamine D1 and D2 receptors, Sulpiride is more selective and acts primarily as a dopamine D2 antagonist. Sulpiride appears to lack effects on norepinephrine, acetylcholine, serotonin, histamine, or gamma-aminobutyric acid (GABA) receptors.
- Sulpiride is absorbed slowly from the gastrointestinal tract. Its oral bioavailability is only 25 to 35% with marked interindividual differences.
Sulpiride has a relatively low order of acute toxicity. Substantial amounts may cause severe but reversible dystonic crises with torticollis, protrusion of the tongue, and/or trism. In some cases all the classical symptoms typical of severe Parkinson's Disease may be noted; in others, over-sedation/coma may occur.
(+-)-Sulpiride | 5-(Aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamide | Levosulpirida | Levosulpiride | Levosulpiridum | N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoylbenzamide | N-((1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-O-anisamide | Sulpirid | Sulpirida | Sulpiridum | Sulpyrid | Sulpiride |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.