DURAPHAT 50MG/ML DENTAL SUSPENSION

Product Information

Registration Status: Active

DURAPHAT 50MG/ML DENTAL SUSPENSION is approved to be sold in Singapore with effective from 1994-07-21. It is marketed by COLGATE-PALMOLIVE (EASTERN) PTE LTD, with the registration number of SIN07802P.

This product contains Sodium Fluoride 50mg/ml in the form of LIQUID. It is approved for DENTAL use.

This product is manufactured by PHARBIL WALTROP GmBH in GERMANY.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Sodium Fluoride

Description

Sodium fluoride is an inorganic chemical compound. A colorless solid, it is a source of the fluoride ion in diverse applications. Sodium fluoride is less expensive and less hygroscopic than the related salt potassium fluoride.

Indication

To prevent cavities.

Mechanism of Action

Fluorides interfere with electron transport and calcium metabolism. Calcium is essential for maintaining cardiac membrane potentials and in regulating coagulation.

Pharmacokinetics

Absorption
Absorbed readily and almost completely from the GI tract. A large amount of an oral dose may be absorbed in the stomach; rate of absorption may depend on the gastric pH.
Distribution
Stored in bones and developing teeth after absorption. Fluoride is distributed into sweat, tears, hair, and saliva. Fluoride crosses the placental barrier and is distributed into breast milk.
Metabolism
Not metabolized.
Elimination

Toxicity

Symptom onset usually occurs within minutes of exposure, but may be delayed. Manifestations of fluoride toxicity are predominantly gastrointestinal (GI), but neurologic and cardiovascular effects also occur.

Active Ingredient/Synonyms

Sodium fluoride | Sodium fluoride |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank