Product Information
Registration Status: ActiveSIN07802P
DURAPHAT 50MG/ML DENTAL SUSPENSION is approved to be sold in Singapore with effective from 1994-07-21. It is marketed by COLGATE-PALMOLIVE (EASTERN) PTE LTD, with the registration number of SIN07802P.
This product contains Sodium Fluoride 50mg/ml in the form of LIQUID. It is approved for DENTAL use.
This product is manufactured by PHARBIL WALTROP GmBH in GERMANY.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
Sodium fluoride is an inorganic chemical compound. A colorless solid, it is a source of the fluoride ion in diverse applications. Sodium fluoride is less expensive and less hygroscopic than the related salt potassium fluoride.
Indication
To prevent cavities.
Mechanism of Action
Fluorides interfere with electron transport and calcium metabolism. Calcium is essential for maintaining cardiac membrane potentials and in regulating coagulation.
Pharmacokinetics
- Absorption
- Absorbed readily and almost completely from the GI tract. A large amount of an oral dose may be absorbed in the stomach; rate of absorption may depend on the gastric pH.
- Distribution
- Stored in bones and developing teeth after absorption. Fluoride is distributed into sweat, tears, hair, and saliva. Fluoride crosses the placental barrier and is distributed into breast milk.
- Metabolism
- Not metabolized.
- Elimination
Toxicity
Symptom onset usually occurs within minutes of exposure, but may be delayed. Manifestations of fluoride toxicity are predominantly gastrointestinal (GI), but neurologic and cardiovascular effects also occur.
Active Ingredient/Synonyms
Sodium fluoride | Sodium fluoride |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.