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FASLODEX SOLUTION FOR INJECTION 250mg/5ML

Product Information

Registration Status: Active

SIN13216P

FASLODEX SOLUTION FOR INJECTION 250mg/5ML is approved to be sold in Singapore with effective from 2006-06-09. It is marketed by ASTRAZENECA SINGAPORE PTE LTD, with the registration number of SIN13216P.

This product contains Fulvestrant 50mg/ml in the form of INJECTION, SOLUTION. It is approved for INTRAMUSCULAR use.

This product is manufactured by Vetter Pharma-Fertigung GmbH in GERMANY.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Product Reference
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Description

Fulvestrant is a drug treatment of hormone receptor-positive metastatic breast cancer in post-menopausal women with disease progression following anti-estrogen therapy. It is an estrogen receptor antagonist with no agonist effects, which works both by down-regulating and by degrading the estrogen receptor.

Indication

For the treatment of hormone receptor positive metastatic breast cancer in postmenopausal women with disease progression following anti-estrogen therapy.

Mechanism of Action

Fulvestrant competitively and reversibly binds to estrogen receptors present in cancer cells and achieves its anti-estrogen effects through two separate mechanisms. First, fulvestrant binds to the receptors and downregulates them so that estrogen is no longer able to bind to these receptors. Second, fulvestrant degrades the estrogen receptors to which it is bound. Both of these mechanisms inhibit the growth of tamoxifen-resistant as well as estrogen-sensitive human breast cancer cell lines.

Toxicity

There is no clinical experience with overdosage in humans.

Active Ingredient/Synonyms

ICI 182,780 | Fulvestrant |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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