FEMOSTON CONTI 1/5 TABLET

Product Information

Registration Status: Active

FEMOSTON CONTI 1/5 TABLET is approved to be sold in Singapore with effective from 2002-11-13. It is marketed by ABBOTT LABORATORIES (SINGAPORE ) PTE LTD, with the registration number of SIN12121P.

This product contains Dydrogesterone 5mg, and Estradiol Hemihydrate 1.03mg in the form of TABLET, FILM-COATED. It is approved for ORAL use.

This product is manufactured by ABBOTT BIOLOGICALS B V in NETHERLANDS.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Dydrogesterone
Estradiol Hemihydrate

Description

A synthetic progestational hormone with no androgenic or estrogenic properties. Unlike many other progestational compounds, dydrogesterone produces no increase in temperature and does not inhibit ovulation. [PubChem]

Indication

Used to treat irregular duration of cycles and irregular occurrence and duration of periods caused by progesterone deficiency. Also used to prevent natural abortion in patients who have a history of habitual abortions.

Mechanism of Action

Dydrogesterone is a progestogen that works by regulating the healthy growth and normal shedding of the womb lining by acting on progesterone receptors in the uterus.

Pharmacokinetics

Absorption
Rapidly absorbed in the gastrointestinal tract with a bioavailability of 28%.
Distribution
Metabolism
Metabolism is complete to a 20-dihydrodydrogesterone (DHD) metabolite.
Elimination

Toxicity

No serious or unexpected toxicity has been observed with dydrogesterone. In acute toxicity studies, the LD50 doses in rats exceeded 4,640mg/kg for the oral route.

Active Ingredient/Synonyms

(9β,10α)-pregna-4,6-diene-3,20-dione | 10alpha-Isopregnenone | 6-Dehydro-retro-progesterone | 9β,10α-pregna-4,6-diene-3,20-dione | delta(6)-Retroprogesterone | delta(Sup 6)-retroprogesterone | Didrogesterona | Didrogesterone | Dydrogesterona | Dydrogestérone | Dydrogesterone | Dydrogesteronum | Gestatron | Hydrogesterone | Hydrogestrone | Isopregnenone | Retro-6-dehydroprogesterone | Dydrogesterone |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.



Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank