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FLORINEF TABLET 0.1mg

Product Information

Registration Status: Active

SIN10680P

FLORINEF TABLET 0.1mg is approved to be sold in Singapore with effective from 1999-01-20. It is marketed by DCH AURIGA SINGAPORE, with the registration number of SIN10680P.

This product contains Fludrocortisone 0.1mg in the form of TABLET. It is approved for ORAL use.

This product is manufactured by ASPEN PHARMA PTY LTD. in GERMANY, andHaupt Pharma Amareg GmbH in AUSTRALIA.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Product Reference
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Description

A synthetic mineralocorticoid with anti-inflammatory activity. [PubChem]

Indication

For partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenogenital syndrome.

Mechanism of Action

Fludrocortisone binds the mineralocorticoid receptor (aldosterone receptor). This binding (or activation of the mineralocorticoid receptor by fludrocortisone) in turn causes an increase in ion and water transport and thus raises extracellular fluid volume and blood pressure and lowers potassium levels.

Toxicity

Effects of overexposure include irritation, cardiac edema, increased blood volume, hypertension, cardiac arrhythmias, enlargement of the heart, headaches, and weakness of the extremities.

Active Ingredient/Synonyms

9alpha-FLUOROCORTISOL | Fludrocortison | Fludrocortisona | Fludrocortisone | Fludrocortisonum | Fluohydrocortisone | Fludrocortisone |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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