Product InformationRegistration Status: Active
FLUANXOL DEPOT INJECTION 20mg/ML is approved to be sold in Singapore with effective from 1988-05-18. It is marketed by LUNDBECK SINGAPORE PTE LTD, with the registration number of SIN01366P.
This product contains Flupenthixol 20mg/ml in the form of INJECTION. It is approved for INTRAMUSCULAR use.
This product is manufactured by H LUNDBECK A/S in DENMARK.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Flupentixol is an antipsychotic neuroleptic drug. It is a thioxanthene, and therefore closely related to the phenothiazines. Its primary use is as a long acting injection given two or three weekly to people with schizophrenia who have a poor compliance with medication and suffer frequent relapses of illness. It is a D1 and D2 receptor antagonist. It is not approved in the United States.
For use in the treatment of schizophrenia and depression
Mechanism of Action
Flupenthixol is a thioxanthene antipsychotic. The mechanism of action of Flupenthixol is not completely understood. Flupenthixol is a powerful antagonist of both D1 and D2 dopamine receptors, and an alpha-adrenergic receptor antagonist. It's antipsychotic activity is thought to be related to blocks postsynaptic dopamine receptors in the CNS.
- Fairly slow and incomplete after oral administration
- Mainly hepatic
LD50=300 mk/kg (Oral in mice); LD50=791 mg/kg (Oral in rats); LD50=87 mk/kg (IV in mice); LD50=37 mg/kg (IV in rats)
Flupenthixol | Flupenthixole | Flupentixol | Flupentixolo | Flupentixolum | Flupentixol |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.