GLUCOBAY 100 TABLET 100mg FOR ORAL USE

Product Information

Registration Status: Active

GLUCOBAY 100 TABLET 100mg is approved to be sold in Singapore with effective from 1994-01-10. It is marketed by BAYER (SOUTH EAST ASIA) PTE LTD, with the registration number of SIN07862P.

This product contains Acarbose 100mg in the form of TABLET. It is approved for ORAL use.

This product is manufactured by BAYER PHARMA AG in GERMANY.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Description

An inhibitor of alpha glucosidase that retards the digestion and absorption of carbohydrates in the small intestine and hence reduces the increase in blood-glucose concentrations after a carbohydrate load. It is given orally to non-insulin dependent diabetes mellitus patients where diet modification or oral hypoglycemic agents do not control their condition. (From Martindale The Extra Pharmacopoeia, 31st ed)

Indication

For treatment and management of diabetes type II (used in combination therapy as a second or third line agent)

Mechanism of Action

Acarbose reversibly bind to pancreatic alpha-amylase and membrane-bound intestinal alpha-glucoside hydrolases. These enzymes inhibit hydrolysis of complex starches to oligosaccharides in the lumen of the small intestine and hydrolysis of oligosaccharides, trisaccharides, and disaccharides to glucose and other monosaccharides in the brush border of the small intestine.

Pharmacokinetics

Absorption: Extremely low bioavailability. Less than 2% of an oral dose of acarbose was absorbed as active drug. Peak plasma concentrations of the active drug were achieved 1 hour after dosing. Drug accumulation does not occur with multiple doses.
Distribution
Metabolism: Acarbose is only metabolized within the gastrointestinal tract by intestinal bacteria and also digestive enzymes to a lesser extent. 4-methylpyrogallol derivatives (sulfate, methyl, and glucuronide conjugates) are the major metabolites. One metabolite (formed by cleavage of a glucose molecule from acarbose) also has alpha-glucosidase inhibitory activity.
Elimination

Toxicity

Gastrointestinal symptoms are the most common reactions to acarbose.

Active Ingredient/Synonyms

Acarbosa | Acarbose | Acarbosum | Acarbose |

Source of information: Drugbank (External Link). Last updated on: 3^rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.