Product Information

Registration Status: Active

GLYPRESSIN SOLUTION FOR INJECTION, 1MG/8.5ML is approved to be sold in Singapore with effective from 2012-04-10. It is marketed by FERRING PHARMACEUTICALS PTE LTD, with the registration number of SIN14244P.

This product contains Terlipressin 0.85mg in the form of INJECTION, SOLUTION. It is approved for INTRAVENOUS use.

This product is manufactured by ZENTIVA k.s. in CZECH REPUBLIC, andFerring Pharmaceuticals (China) Co. in CHINA.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.



Terlipressin is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. It has been found to be effective when norepinephrine does not help.


Commonly used to stop bleeding of varices in the food pipe (oesophagus).

Mechanism of Action

Terlipressin, an analogue of vasopressin, acts on three different receptors, vasopressin receptor V1a (which initiates vasoconstriction, liver gluconeogenesis, platelet aggregation and release of factor VIII), vasopressin receptor V1b (which mediates corticotrophin secretion from the pituitary) and vasopressin receptor V2 which controls free water reabsorption in the renal medullar. The binding of terlipressin to the V2 receptor activates adenylate cyclase which causes the release of aquaporin 2 channels into the cells lining the renal medullar duct. This allows water to be reabsorbed down an osmotic gradient so the urine is more concentrated.

Active Ingredient/Synonyms

Terlipressin | Terlipressina | Terlipressine | Terlipressinum | Terlipressin |

Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.


  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank