Product Information
Registration Status: ActiveSIN06722P
HEMABATE INJECTION 250mcg/ML is approved to be sold in Singapore with effective from 1991-11-29. It is marketed by PFIZER PTE LTD, with the registration number of SIN06722P.
This product contains Carboprost Tromethamine 250mcg/ml in the form of INJECTION. It is approved for INTRAMUSCULAR use.
This product is manufactured by Pharmacia & Upjohn Company in UNITED STATES.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
A nonsteroidal abortifacient agent that is effective in both the first and second trimesters of pregnancy. [PubChem]
Indication
For aborting pregnancy between the 13th and 20th weeks of gestation as calculated from the first day of the last normal menstrual period and in the following conditions related to second trimester abortion: 1. Failure of expulsion of the fetus during the course of treatment by another method; 2. Premature rupture of membranes in intrauterine methods with loss of drug and insufficient or absent uterine activity; 3. Requirement of a repeat intrauterine instillation of drug for expulsion of the fetus; 4. Inadvertent or spontaneous rupture of membranes in the presence of a previable fetus and absence of adequate activity for expulsion. Also for the treatment of postpartum hemorrhage due to uterine atony which has not responded to conventional methods of management.
Mechanism of Action
Carboprost is a synthetic prostaglandin. It binds the prostaglandin E2 receptor, causing myometrial contractions, casuing the induction of labour or the expulsion of the placenta. Prostaglandins occur naturally in the body and act at several sites in the body including the womb (uterus). They act on the muscles of the womb, causing them to contract.
Toxicity
Symptoms of overdose include irritation, nausea, vomiting, diarrhea, coughing, dyspnea, asthma, hypertension, flushing, and pyrexia.
Active Ingredient/Synonyms
(15S)-15-Methyl-pgf2alpha tromethamine salt | (15S)-15-Methylprostaglandin F2alpha tromethamine | 1,3-Dihydroxy-2-(hydroxymethyl)propan-2-aminium (5Z,9alpha,11beta,13e,15S)-9,11,15-trihydroxy-15-methylprosta-5,13-dien-1-oate | 15(S)-15-Methyl-pgf2alpha tromethamine salt | 15(S)-15-Methylprostaglandin F2alpha tromethamine | Carboprost | Carboprost trometamol | Methyldinoprost | Carboprost Tromethamine |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.