Product Information
Registration Status: ActiveHERBESSER FOR INJECTION 10mg/AMPOULE is approved to be sold in Singapore with effective from 1991-05-06. It is marketed by PHARMAFORTE SINGAPORE PTE LTD, with the registration number of SIN06013P.
This product contains Diltiazem 10mg/ampoule in the form of INJECTION, POWDER, FOR SOLUTION. It is approved for INTRAVENOUS use.
This product is manufactured by MITSUBISHI TANABE PHARMA CORPORATION in JAPAN.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Description
A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions. It is also teratogenic.
Indication
For the treatment of Hypertension
Mechanism of Action
Possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, diltiazem, like verapamil, inhibits the influx of extracellular calcium across both the myocardial and vascular smooth muscle cell membranes. The resultant inhibition of the contractile processes of the myocardial smooth muscle cells leads to dilation of the coronary and systemic arteries and improved oxygen delivery to the myocardial tissue.
Pharmacokinetics
- Absorption
- Diltiazem is well absorbed from the gastrointestinal tract but undergoes substantial hepatic first-pass effect.
- Distribution
- Metabolism
- Diltiazem is metabolized by and acts as an inhibitor of the CYP3A4 enzyme.
- Elimination
Toxicity
LD50=740mg/kg (orally in mice)
Active Ingredient/Synonyms
(+)-cis-5-[2-(dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate ester | (2S-cis)-3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one | (2S,3S)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate | Acetic acid (2S,3S)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester | D-cis-diltiazem | Diltiazem | Diltiazemum | Diltiazem |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.