Product InformationRegistration Status: Active
HEXENE-FORTE TABLET 500mg is approved to be sold in Singapore with effective from 1988-09-05. It is marketed by SUNWARD PHARMACEUTICAL PTE LTD, with the registration number of SIN00899P.
This product contains Griseofulvin 500mg in the form of TABLET. It is approved for ORAL use.
This product is manufactured by SUNWARD PHARMACEUTICAL PTE LTD in SINGAPORE.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. [PubChem]
For the treatment of ringworm infections of the skin, hair, and nails, namely: tinea corporis, tinea pedis, tinea cruris, tinea barbae, cradle cap or other conditions caused by Trichophyton or Microsporum fungi.
Mechanism of Action
Griseofulvin is fungistatic, however the exact mechanism by which it inhibits the growth of dermatophytes is not clear. It is thought to inhibit fungal cell mitosis and nuclear acid synthesis. It also binds to and interferes with the function of spindle and cytoplasmic microtubules by binding to alpha and beta tubulin. It binds to keratin in human cells, then once it reaches the fungal site of action, it binds to fungal microtubes thus altering the fungal process of mitosis.
- Poorly absorbed from GI ranging from 25 to 70% of an oral dose. Absorption is significantly enhanced by administration with or after a fatty meal.
- Primarily hepatic with major metabolites being 6-methyl-griseofulvin and its glucuronide conjugate.
Side effects are minor: headaches, gastrointestinal reactions and cutaneous eruptions
(+)-griseofulvin | Amudane | Curling factor | Fulcin | Fulvicin | Grifulvin | Griseofulvin | Griseofulvin, microcrystalline | Griseofulvin, ultramicrosize | Griseofulvina | Griseofulvine | Griseofulvinum | Grisovin | Grysio | Lamoryl | Likuden | Poncyl | Spirofulvin | Sporostatin | Griseofulvin |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.