Product Information

Registration Status: Active

HYALASE POWDER FOR INJECTION 1500 IU/AMPOULE is approved to be sold in Singapore with effective from 1998-10-23. It is marketed by MEDIPHARM PTE LTD, with the registration number of SIN10302P.

This product contains Hyaluronidase (Ovine) 1500 iu/ampoule in the form of INJECTION, POWDER, FOR SOLUTION. It is approved for INTRAVENOUS use.

This product is manufactured by CP PHARMACEUTICALS LTD in UNITED KINGDOM.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Hyaluronidase (Ovine)


Highly purified sheep hyaluronidase for administration by injection into the vitreous of the eye.


For increase of absorption and distribution of other injected drugs and for rehydration.

Mechanism of Action

Hyaluronidase is a spreading or diffusing substance. It increase the permeability of connective tissue through the hydrolysis of hyaluronic acid. Hyaluronidase hydrolyzes hyaluronic acid by splitting the glucosaminidic bond between C1 of the glucosamine moiety and C4 of glucuronic acid. This temporarily decreases the viscosity of the cellular cement and increases diffusion of injected fluids or of localized transudates or exudates, thus facilitating their absorption.

Active Ingredient/Synonyms

HYAL-1 | Hyaluronidase (glycoprotein, sheep testis isoenzyme) | Hyaluronidase (ovine) | Hyaluronidase (sheep testis isoenzyme) | Hyaluronidase 1 precursor | Hyaluronidase PH-20 | Hyaluronidase, ovine | Ovine hyaluronidase | Sperm adhesion molecule 1 | Sperm surface protein PH-20 | Hyaluronidase |

Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.


  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank