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HYPERNOL 100 TABLET 100mg

Product Information

Registration Status: Inactive

SIN08754P

THIS PRODUCT HAS BEEN DEREGISTERED!

HYPERNOL 100 TABLET 100mg is approved to be sold in Singapore with effective from 1996-06-20. It is marketed by DRUG HOUSES OF AUSTRALIA PTE LTD, with the registration number of SIN08754P.

This product contains Atenolol 100mg in the form of TABLET, FILM-COATED. It is approved for ORAL use.

This product is manufactured by DRUG HOUSES OF AUSTRALIA PTE LTD in SINGAPORE.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Product Reference
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Description

A cardioselective beta-adrenergic blocker possessing properties and potency similar to propranolol, but without a negative inotropic effect.

Indication

For the management of hypertention and long-term management of patients with angina pectoris

Mechanism of Action

Like metoprolol, atenolol competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle, inhibiting sympathetic stimulation. This results in a reduction in resting heart rate, cardiac output, systolic and diastolic blood pressure, and reflex orthostatic hypotension. Higher doses of atenolol also competitively block beta(2)-adrenergic responses in the bronchial and vascular smooth muscles.

Pharmacokinetics

Absorption
Approximately 50% of an oral dose is absorbed from the gastrointestinal tract, the remainder being excreted unchanged in the feces.
Distribution
Metabolism
Hepatic (minimal)
Elimination

Toxicity

LD50=2000-3000 mg/kg(orally in mice). Symptoms of an atenolol overdose include a slow heart beat, shortness of breath, fainting, dizziness, weakness, confusion, nausea, and vomiting.

Active Ingredient/Synonyms

1-p-Carbamoylmethylphenoxy-3-isopropylamino-2-propanol | 2-(p-(2-Hydroxy-3-(isopropylamino)propoxy)phenyl)acetamide | 4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)benzeneacetamide | Atenololum | Atenolol |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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