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INPANOL TABLET 10mg

Product Information

Registration Status: Active

SIN00076P

INPANOL TABLET 10mg is approved to be sold in Singapore with effective from 1988-02-24. It is marketed by DRUG HOUSES OF AUSTRALIA PTE LTD, with the registration number of SIN00076P.

This product contains Propranolol 10mg in the form of TABLET. It is approved for ORAL use.

This product is manufactured by PT ACTAVIS INDONESIA in INDONESIA REP OF.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Product Reference
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Description

A widely used non-cardioselective beta-adrenergic antagonist. Propranolol is used in the treatment or prevention of many disorders including acute myocardial infarction, arrhythmias, angina pectoris, hypertension, hypertensive emergencies, hyperthyroidism, migraine, pheochromocytoma, menopause, and anxiety. [PubChem]

Indication

For the prophylaxis of migraine.

Mechanism of Action

Propranolol competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart, inhibiting sympathetic stimulation. This results in a reduction in resting heart rate, cardiac output, systolic and diastolic blood pressure, and reflex orthostatic hypotension.

Pharmacokinetics

Absorption
Propranolol is almost completely absorbed from the GI tract; however, plasma concentrations attained are quite variable among individuals.
Distribution
* 4 L
Metabolism
Hepatic
Elimination

Toxicity

Symptoms of overdose include bradycardia, cardiac failure, hypotension, and brochospasm. LD50=565 mg/kg (orally in mice).

Active Ingredient/Synonyms

1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol | 1-(isopropylamino)-3-(1-naphthyloxy)propan-2-ol | beta-Propranolol | Propanalol | Propanolol | Propranolol | Propranololo | Propranololum | β-Propranolol | Propranolol |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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