Product Information
Registration Status: ActiveIPROVENT INHALER 20mcg/PUFF is approved to be sold in Singapore with effective from 2012-10-23. It is marketed by DRUG HOUSES OF AUSTRALIA PTE LTD, with the registration number of SIN14257P.
This product contains Ipratropium 20mcg/dose in the form of AEROSOL, METERED. It is approved for RESPIRATORY (INHALATION) use.
This product is manufactured by Laboratorio ALDO-UNIN S.A. in SPAIN.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Description
A muscarinic antagonist structurally related to atropine but often considered safer and more effective for inhalation use. It is used for various bronchial disorders, in rhinitis, and as an antiarrhythmic.
Indication
For maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease, including chronic bronchitis and emphysema.
Mechanism of Action
Ipratropium bromide is an anticholinergic agent. It blocks muscarinic cholinergic receptors, without specificity for subtypes, resulting in a decrease in the formation of cyclic guanosine monophosphate (cGMP). Most likely due to actions of cGMP on intracellular calcium, this results in decreased contractility of smooth muscle.
Pharmacokinetics
- Absorption
- Inhalation (local)-minimal; Nasal-rapid and minimal
- Distribution
- * 4.6 L/kg
- Metabolism
- Partially metabolized to at least 8 metabolites formed primarily via hydrolysis and conjugation. The main metabolites are N-isopropylnortropium methobromide, which is formed by enzymatic hydrolysis of the ester; α-phenylacrylic acid-N-isopropylnortropine-ester methobromide, which is formed by enzymatic loss of a water; and phenylacetic acid-N-isopropylnortropine-ester methobromide, which is formed by enzymatic loss of a CH3OH-group. These metabolites appear to be inactive.
- Elimination
Clearance
* 2.3 L/min (total clearance of active ingredient)
Toxicity
LD50=1001mg/kg (orally in mice)
Active Ingredient/Synonyms
Ipratropium cation | Ipratropium ion | Ipratropium |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.