Product Information
Registration Status: ActiveSIN00344P
ISOPTIN SR TABLET 240mg is approved to be sold in Singapore with effective from 1988-04-22. It is marketed by ABBOTT LABORATORIES (SINGAPORE ) PTE LTD, with the registration number of SIN00344P.
This product contains Verapamil 240mg in the form of TABLET, FILM-COATED. It is approved for ORAL use.
This product is manufactured by AbbVie Deutschland GmbH & Co. Kg in GREECE, andFamar A.V.E. Anthoussa Plant in GERMANY.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
A calcium channel blocker that is a class IV anti-arrhythmia agent.
Indication
For the treatment of hypertension, angina, and cluster headache prophylaxis.
Mechanism of Action
Verapamil inhibits voltage-dependent calcium channels. Specifically, its effect on L-type calcium channels in the heart causes a reduction in ionotropy and chronotropy, thuis reducing heart rate and blood pressure. Verapamil's mechanism of effect in cluster headache is thought to be linked to its calcium-channel blocker effect, but which channel subtypes are involved is presently not known.
Pharmacokinetics
- Absorption
- 90%
- Distribution
- Metabolism
- Elimination
Toxicity
LD50=8 mg/kg (i.v. in mice)
Active Ingredient/Synonyms
Iproveratril | Vérapamil | Verapamil | Verapamilo | Verapamilum | Verapamil |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.