Product Information
Registration Status: ActiveSIN11696P
LEUKERAN TABLET 2mg (REVISED FORMULA) is approved to be sold in Singapore with effective from 2001-11-10. It is marketed by DCH AURIGA SINGAPORE, with the registration number of SIN11696P.
This product contains Chlorambucil 2mg in the form of TABLET, FILM-COATED. It is approved for ORAL use.
This product is manufactured by Excella GmbH in GERMANY.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
Indication
For treatment of chronic lymphatic (lymphocytic) leukemia, childhood minimal-change nephrotic syndrome, and malignant lymphomas including lymphosarcoma, giant follicular lymphoma, Hodgkin's disease, non-Hodgkin's lymphomas, and Waldenström’s Macroglobulinemia.
Mechanism of Action
Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations.
Active Ingredient/Synonyms
4-(P-Bis(beta-chloroethyl)aminophenyl)butyric acid | 4-(p-bis(β-chloroethyl)aminophenyl)butyric acid | 4-[p-[bis(2-chloroethyl)amino]phenyl]butyric acid | Ambochlorin | CHLORAMBUCIL | Chloraminophen | gamma-[P-Di(2-chloroethyl)aminophenyl]butyric acid | N,N-Di-2-chloroethyl-gamma-P-aminophenylbutyric acid | N,N-di-2-chloroethyl-γ-p-aminophenylbutyric acid | Phenylbutyric Acid Nitrogen Mustard | γ-[p-di(2-chloroethyl)aminophenyl]butyric acid | Chlorambucil |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.