Product Information
Registration Status: ActiveMEIXAM POWDER FOR SOLUTION FOR INJECTION 500MG/VIAL is approved to be sold in Singapore with effective from 2019-10-21. It is marketed by DUOPHARMA (SINGAPORE) PTE LTD, with the registration number of SIN15834P.
This product contains Cloxacillin 500mg/vial in the form of INJECTION, POWDER, FOR SOLUTION. It is approved for INTRAVENOUS, INTRAMUSCULAR use.
This product is manufactured by PT. MEIJI INDONESIA in INDONESIA REP OF.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Description
A semi-synthetic antibiotic that is a chlorinated derivative of oxacillin.
Indication
Used to treat infections caused by penicillinase-producing staphylococci, including pneumococci, group A beta-hemolytic streptococci, and penicillin G-sensitive and penicillin G-resistant staphylococci.
Mechanism of Action
By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, cloxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cloxacillin interferes with an autolysin inhibitor.
Pharmacokinetics
- Absorption
- Well absorbed from the gastrointestinal tract.
- Distribution
- Metabolism
- Elimination
Toxicity
Oral LD50 in rat and mouse is 5000 mg/kg. Intravenous LD50 in rat is 1660 mg/kg. Symptoms of overdose include wheezing, tightness in the chest, fever, itching, bad cough, blue skin color, fits, and swelling of face, lips, tongue, or throat.
Active Ingredient/Synonyms
(2S,5R,6R)-6-({[3-(2-chlorophenyl)-5-methylisoxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid | (3-(O-Chlorophenyl)-5-methyl-4-isoxazolyl)penicillin | 6-(3-(O-Chlorophenyl)-5-methyl-4-isoxazolecarboxamido)penicillanic acid | Cloxacilina | Cloxacilline | Cloxacillinum | Cloxacillin |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.