Product Information

Registration Status: Active

MESTINON TABLET 60mg is approved to be sold in Singapore with effective from 1989-05-22. It is marketed by A. MENARINI SINGAPORE PTE LTD, with the registration number of SIN02898P.

This product contains Pyridostigmine 60mg in the form of TABLET, SUGAR-COATED. It is approved for ORAL use.

This product is manufactured by LABIANA PHARMACEUTICALS S.L.U in SPAIN.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.



A cholinesterase inhibitor with a slightly longer duration of action than neostigmine. It is used in the treatment of myasthenia gravis and to reverse the actions of muscle relaxants. [PubChem]


For the treatment of myasthenia gravis.

Mechanism of Action

Pyridostigmine inhibits acetylcholinesterase in the synaptic cleft by competing with acetylcholine for attachment to acetylcholinesterase, thus slowing down the hydrolysis of acetylcholine, and thereby increases efficiency of cholinergic transmission in the neuromuscular junction and prolonges the effects of acetylcholine.


Poorly absorbed from the GI tract with an oral bioavailability of 7.6 +/- 2.4%.
Hydrolysis by cholinesterases and by liver.

Active Ingredient/Synonyms

Bromure de Pyridostigmine | Bromuro de piridostigmina | Pyridostigmin bromid | Pyridostigmine | Pyridostigmini Bromidum | Pyridostigmine |

Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.


  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank