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METHYLPREDNISOLONE POWDER FOR SOLUTION FOR INJECTION 500MG

Product Information

Registration Status: Active

SIN14594P

METHYLPREDNISOLONE POWDER FOR SOLUTION FOR INJECTION 500MG is approved to be sold in Singapore with effective from 2014-08-26. It is marketed by MYLAN PHARMACEUTICALS PTE LTD, with the registration number of SIN14594P.

This product contains Methylprednisolone 500mg in the form of INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION. It is approved for INTRAVENOUS use.

This product is manufactured by Agila Specialties PTE LTD ( Speciality Formulation Facility) in INDIA.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Product Reference
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Description

A prednisolone derivative with similar anti-inflammatory action. [PubChem]

Indication

Adjunctive therapy for short-term administration in rheumatoid arthritis.

Mechanism of Action

Unbound glucocorticoids cross cell membranes and bind with high affinity to specific cytoplasmic receptors, modifying transcription and protein synthesis. By this mechanism, glucocorticoids can inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, and suppress humoral immune responses. The antiinflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.

Pharmacokinetics

Absorption
Oral bioavailability 80-99%
Distribution
Metabolism
Hepatic
Elimination

Toxicity

LD50=2000 mg/kg (orally in rat)

Active Ingredient/Synonyms

(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione | (6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione | 1-dehydro-6alpha-Methylhydrocortisone | 1-dehydro-6α-methylhydrocortisone | 6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione | delta(1)-6alpha-Methylhydrocortisone | Medrate | Medrone | Methylprednisolon | Methylprednisolone | Methylprednisolonum | Metilprednisolona | Solomet | Urbason | Methylprednisolone |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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