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MINIMS ATROPINE SULFATE EYE DROPS 1% W/V

Product Information

Registration Status: Active

SIN04317P

MINIMS ATROPINE SULFATE EYE DROPS 1% W/V is approved to be sold in Singapore with effective from 1990-04-23. It is marketed by BAUSCH & LOMB (SINGAPORE) PTE LTD, with the registration number of SIN04317P.

This product contains Atropine 1% w/v in the form of SOLUTION. It is approved for OPHTHALMIC use.

This product is manufactured by LABORATOIRE CHAUVIN SA in FRANCE.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Product Reference
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Description

An alkaloid, originally from Atropa belladonna, but found in other plants, mainly solanaceae. [PubChem]

Indication

For the treatment of poisoning by susceptible organophosphorous nerve agents having anti-cholinesterase activity (cholinesterase inhibitors) as well as organophosphorous or carbamate insecticides.

Mechanism of Action

Atropine binds to and inhibit muscarinic acetylcholine receptors, producing a wide range of anticholinergic effects.

Pharmacokinetics

Absorption
Atropine is rapidly and well absorbed after intramuscular administration. Atropine disappears rapidly from the blood and is distributed throughout the various body tissues and fluids.
Distribution
Metabolism
Much of the drug is destroyed by enzymatic hydrolysis, particularly in the liver. From 13 to 50% is excreted unchanged in the urine.
Elimination

Toxicity

Oral, mouse: LD50 = 75 mg/kg. Symptoms of overdose includes widespread paralysis of parasympathetically innervated organs. Dry mucous membranes, widely dilated and nonresponsive pupils, tachycardia, fever and cutaneous flush are especially prominent, as are mental and neurological symptoms. In instances of severe intoxication, respiratory depression, coma, circulatory collapse and death may occur.

Active Ingredient/Synonyms

(+-)-Atropine | (+-)-Hyoscyamine | (+,-)-Tropyl tropate | (±)-atropine | (±)-hyoscyamine | (3-Endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl tropate | [(1S,5R)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl] 3-hydroxy-2-phenyl-propanoate | 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate | 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl tropate | Atropin | Atropina | Atropine | Atropinum | dl-Hyoscyamine | dl-tropyltropate | Mydriasine | Tropine tropate | Atropine |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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