Product Information
Registration Status: ActiveMUPRIN OINTMENT 2% W/W is approved to be sold in Singapore with effective from 2013-10-30. It is marketed by ZUELLIG PHARMA PTE LTD, with the registration number of SIN14421P.
This product contains Mupirocin 2.00% w/w in the form of OINTMENT. It is approved for TOPICAL use.
This product is manufactured by Hoe Pharmaceuticals Sdn. Bhd. in MALAYSIA.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Description
Mupirocin (pseudomonic acid A, or Bactroban or Centany) is an antibiotic originally isolated from Pseudomonas fluorescens. It is used topically, and is primarily effective against Gram-positive bacteria. Mupirocin is bacteriostatic at low concentrations and bactericidal at high concentrations. Mupirocin has a unique mechanism of action, which is selective binding to bacterial isoleucyl-tRNA synthetase, which halts the incorporation of isoleucine into bacterial proteins. Because this mechanism of action is not shared with any other antibiotic, mupirocin has few problems of antibiotic cross-resistance.
Indication
For the treatment of Staphylococci nasal carriers.
Mechanism of Action
Mupirocin reversibly binds to bacterial isoleucyl-tRNA synthetase, an enzyme which promotes the conversion of isoleucine and tRNA to isoleucyl-tRNA. Prevention of this enzymes from functioning properly results in the inhibition of bacterial protein and RNA synthesis.
Pharmacokinetics
- Absorption
- No measurable systemic absorption
- Distribution
- Metabolism
- Hepatic. Following intravenous or oral administration, mupirocin is rapidly metabolized. The principal metabolite is monic acid, which has no antibacterial activity.
- Elimination
Active Ingredient/Synonyms
9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3- [(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl] oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoic acid | Mupirocina | Mupirocine | Mupirocinum | Pseudomonic acid | Pseudomonic acid a | Mupirocin |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.