Product Information
Registration Status: ActiveSIN14421P
MUPRIN OINTMENT 2% W/W is approved to be sold in Singapore with effective from 2013-10-30. It is marketed by ZUELLIG PHARMA PTE LTD, with the registration number of SIN14421P.
This product contains Mupirocin 2.00% w/w in the form of OINTMENT. It is approved for TOPICAL use.
This product is manufactured by Hoe Pharmaceuticals Sdn. Bhd. in MALAYSIA.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
Mupirocin (pseudomonic acid A, or Bactroban or Centany) is an antibiotic originally isolated from Pseudomonas fluorescens. It is used topically, and is primarily effective against Gram-positive bacteria. Mupirocin is bacteriostatic at low concentrations and bactericidal at high concentrations. Mupirocin has a unique mechanism of action, which is selective binding to bacterial isoleucyl-tRNA synthetase, which halts the incorporation of isoleucine into bacterial proteins. Because this mechanism of action is not shared with any other antibiotic, mupirocin has few problems of antibiotic cross-resistance.
Indication
For the treatment of Staphylococci nasal carriers.
Mechanism of Action
Mupirocin reversibly binds to bacterial isoleucyl-tRNA synthetase, an enzyme which promotes the conversion of isoleucine and tRNA to isoleucyl-tRNA. Prevention of this enzymes from functioning properly results in the inhibition of bacterial protein and RNA synthesis.
Pharmacokinetics
- Absorption
- No measurable systemic absorption
- Distribution
- Metabolism
- Hepatic. Following intravenous or oral administration, mupirocin is rapidly metabolized. The principal metabolite is monic acid, which has no antibacterial activity.
- Elimination
Active Ingredient/Synonyms
9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3- [(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl] oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoic acid | Mupirocina | Mupirocine | Mupirocinum | Pseudomonic acid | Pseudomonic acid a | Mupirocin |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.