Product Information
Registration Status: ActiveSIN01978P
NALOL TABLET 40mg is approved to be sold in Singapore with effective from 1988-06-23. It is marketed by SUNWARD PHARMACEUTICAL PTE LTD, with the registration number of SIN01978P.
This product contains Propranolol 40mg in the form of TABLET. It is approved for ORAL use.
This product is manufactured by SUNWARD PHARMACEUTICAL PTE LTD in SINGAPORE.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
A widely used non-cardioselective beta-adrenergic antagonist. Propranolol is used in the treatment or prevention of many disorders including acute myocardial infarction, arrhythmias, angina pectoris, hypertension, hypertensive emergencies, hyperthyroidism, migraine, pheochromocytoma, menopause, and anxiety. [PubChem]
Indication
For the prophylaxis of migraine.
Mechanism of Action
Propranolol competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart, inhibiting sympathetic stimulation. This results in a reduction in resting heart rate, cardiac output, systolic and diastolic blood pressure, and reflex orthostatic hypotension.
Pharmacokinetics
- Absorption
- Propranolol is almost completely absorbed from the GI tract; however, plasma concentrations attained are quite variable among individuals.
- Distribution
- * 4 L
- Metabolism
- Hepatic
- Elimination
Toxicity
Symptoms of overdose include bradycardia, cardiac failure, hypotension, and brochospasm. LD50=565 mg/kg (orally in mice).
Active Ingredient/Synonyms
1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol | 1-(isopropylamino)-3-(1-naphthyloxy)propan-2-ol | beta-Propranolol | Propanalol | Propanolol | Propranolol | Propranololo | Propranololum | β-Propranolol | Propranolol |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.